April 2, 2007
Gilead Sciences, Inc. is the first customer of Strand Life Sciences' SAR modelling and deployment platform - Sarchitect.
Two editions of the Sarchitect product have been launched, Designer - for use by computational scientists, and Miner - for in silico lead optimization by medicinal chemists. Sarchitect Designer provides the latest methods in machine learning-based algorithms supported by workflows that guide users through building ‘best-possible’ models on their data. It allows assessing confidence in models and prediction by computing metrics such as, structure/sub-structure similarity, descriptor space similarity and chemical space comparisons. Sarchitect Miner allows medicinal chemists to use models in profiling molecules across various target properties, including popular ADME/Tox endpoints. A real-time ‘edit & predict’ feature allows chemists to perform interactive lead optimization. Sarchitect operates under an ‘open model’ framework - all models, including those from the pre-built collection, come with the data and information used in the building process.
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